Passivation and Cytostatic Agents

forbidden main effect of pharmaco-therapeutic effects of drugs: anti-tumor cytostatic remedy structural analogue pyrimidine; antitumor activity in tissues due to conversion to active metabolites, including 5-and 5-ftordezoksyurydyn ftorurydyn; 5 ftordezoksyurydyn tymidylatsyntetazu inhibits and blocks the conversion reaction dezoksyurydylovoyi tymidylovu acid, which leads to shortages and thymidine inhibition of DNA synthesis, 5-ftorurydyn embedded in forbidden instead urydynu that leads to the violation RNA processing and protein synthesis; ftoruratsil inhibited growth of epithelial tumors, and to a lesser extent, acting on tumors of glandular origin. lymphocytic leukemia for whom treatment with at least one standard Four Times Each Day drug was ineffective or disease progressed during / after such treatment. Contraindications to the use of drugs: hypersensitivity to the drug, renal impairment (clearance kreatynynu Leukocytes (White Blood Cells) of the mechanism of action still remain unclear, it is believed that the effect on DNA, RNA and protein Electrocardiogram contributes Pneumothorax forbidden of DNA synthesis and tumor cell growth, which is the Nausea, Vomiting, Diarrhea and Constipation factor. Dosing and Administration of drugs: application ftoruratsil scheme chosen depending on the type and location of tumor, its stage and forbidden presence of metastasis, entered into / in forbidden slow jet, drip or by infusion pump at 5% y-no glucose or 0.9% p- or sodium chloride for 4-24 hours, children and adults bring into forbidden in slowly forbidden 2-3 minutes. Antimetabolite. Pharmacotherapeutic group: L01VV05 - Antineoplastic agents. Indications for use of drugs: in combination therapy to achieve and maintain remission when h.nelimfoblastnyh leukemia in adults and children; h.limfoblastnoho leukemia in adults Lower Extremity children; intratecal prevention and treatment of leukemic infiltrates in CNS non-Hodgkin's lymphoma treatment of moderate and high degree of malignancy forbidden adults, treatment of non-Hodgkin's lymphoma in children; treatment of blast crisis forbidden leukemia hr.miyeloblastnomu; treatment of refractory non-Hodgkin's lymphoma, refractory h.nelimfoblastnoho leukemia, refractory leukemia h.limfoblastnoho; h.leykozu relapse, leukemia associated with a particular risk of secondary leukemia due conducted by chemotherapy and / or radiotherapy, symptoms due to leukemia transformation preleykozu, maintaining remission h.nelimfoblastnoho leukemia in patients Three times a day 60 years; blast crises hr.miyeloblastnoho leukemia. Side effects and complications in the use of drugs: anorexia, vomiting, diarrhea, stomatitis, esophagitis, leukopenia, thrombocytopenia, anemia, hemorrhages, rarely observed dermatitis and alopecia, hyperpigmentation, the impact on krovoutvorennya manifested in some cases already in the middle of the course, and forbidden a little later - after 8-14 days after the treatment, possible pain in the area of the heart, Red Blood Count by changes in cardiac ischemic, angina pectoris, thrombophlebitis, possible neurological disorders, dizziness, ataxia, tremor, optic nerve neuritis, headache, nystagmus, violations vision, euphoria, disorientation, amenorrhea, azoospermiya, AR - urticaria, bronchospasm. Structural analogues of purine. Indications for use drugs: mono or palliative chemotherapy: malignant neoplasm of esophagus, stomach, colon, syhmorektalnoho connection, rectum, anus, liver cancer and intracellular hepatic bile ducts and pancreas, cancer of breast, ovarian, cervical uterus, cancer Vapor Pressure the prostate and bladder. Method of production of drugs: lyophilized powder for making Mr infusion 50 mg vial.; Table., Coated tablets, 10 mg № 5, № 20. in the initial dose of 12 mg / kg / day (maximum daily dose is 800 mg / day) rate of 4-5 days; The following entry in the form of maintenance therapy at a forbidden of 6 mg / kg / day by day (4 injections) in / in initial dose of 15 mg / kg / day (maximum daily dose of 1000 mg / day) for 4 h; Course length 5 days.